The Molecular Condom - vaginal gel releases Anti-HIV drug when exposed to semen
from Health and Wellbeing (377 articles)
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December 13, 2006 Once likened to “taking a shower with a raincoat on”, the condom may be the safest method of protection during sex, but it significantly detracts from the experience. Last week we featured the spray-on condom designed to offer a better fit but we’re betting that new work being done by University of Utah scientists will get a lot of attention due to its likelihood of overcoming the many shortcomings of the condom. It is in fact a "molecular condom" for use by women. The liquid is vaginally inserted daily and prevents AIDS by turning into a gel-like coating and when exposed to semen, returning to liquid form and releasing an antiviral drug. The ultimate hope for this technology is to protect women and their unborn or nursing children from the AIDS virus, but the molecular condom is five years away from tests in humans and roughly 10 years until it might be in widespread use.
"We have developed a new vaginal gel that we call a molecular condom because it is composed of molecules that are liquid at room temperature and, when applied in the vagina, will spread and turn into a gel and effectively coat the tissue," says Patrick Kiser, an assistant professor of bioengineering. "It's a smart molecular condom because we designed this gel to release anti-HIV drugs when the gel comes into contact with semen during intercourse."
Kiser and colleagues report development of the molecular condom in a study to be published online Monday, Dec. 11, 2006, in the Journal of Pharmaceutical Sciences.
The molecular condom is part of a worldwide research effort to develop "microbicides" – drug-delivery systems such as gels, rings, sponges or creams to prevent infection by the human immunodeficiency virus and other sexually transmitted diseases. HIV causes AIDS, which cripples the immune system, leaving patients vulnerable to other infections, cancers and death.
Microbicides are seen as a way for women to gain power by protecting themselves from HIV, particularly in impoverished nations where AIDS is widespread, where rape is rampant or where conventional condoms are taboo, not reliably available or where men resist using them. Worldwide, most AIDS cases are spread heterosexually.
About 16 microbicides are in development and five are undergoing testing in thousands of women, mostly in Africa. They are designed to fight HIV infection by preventing the virus from entering cells or replicating, or by maintaining acidic vaginal conditions. No first-generation microbicide has been approved yet for wide use.
Delivering Anti-HIV Medicine When and Where Needed
Kiser says the University of Utah molecular condom would be a more advanced method of delivering an antiviral drug to prevent infection by the AIDS virus.
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